PRP tau ntev tau txhais tias yog autologous plasma uas muaj cov ntsiab lus ntawm platelets ntau dua li cov ntshav ib txwm muaj.Cov teebmeem ntawm PRP cia siab rau qhov tshwj xeeb lom neeg ntawm platelets thiab lawv cov kev koom tes hauv qhov txhab kho qhov txhab.Lub luag haujlwm tseem ceeb ntawm platelets yog tsim kom muaj lub hemostatic ntsaws thiab txhawb kev tsim cov fibrin thiab cov ntshav txhaws kom tsis txhob poob ntshav.Txawm li cas los xij, lawv kuj yog ib feem tseem ceeb ntawm lub cev tiv thaiv kab mob.Lawv tiv thaiv kev kis kab mob thiab hloov kho qhov mob, lawv txhawb cov cell chemotaxis thiab kev loj hlob, thiab lawv txhawb kev kho mob, angiogenesis, thiab pob txha tsim.
Hauv cov platelets, qhov ntau tshaj ntawm cov proteins secreted yog α-granule.Cov proteins uas zais cia tuaj yeem muab faib ua cov tsev neeg sib txawv raws li lawv txoj haujlwm lom neeg.Cov yam ntxwv xws li PDGF, IGF-1, VEGF, thiab ntau lwm yam tshuaj chemokines thiab cytokines nyiam qhov txhab kho thiab txhawb kev mob angiogenesis hauv kev koom tes nrog cov neeg kho mob proangiogenic xws li SDF-1, MMP-1, MMP-2, MMP-9, thiab angiopoietin uas yog kuj tam sim no.FGF-2 yog ib qho mitogenic yam zoo li TGF-β1 uas tseem paub los nrhiav cov kab mob inflammatory rau lub qhov txhab.IGF-1 stimulates matrix formation.Adhesion proteins uas tuaj yeem ua raws li cov cell adhesion molecules yog li kho cov cell migration kuj tso tawm los ntawm platelets. .
Cov proinflammatory molecule CD40 ligand tam sim no nyob rau hauv platelet membranes ntseeg tau tias ua lub luag haujlwm tseem ceeb hauv stimulating angiogenesis los ntawm kev txhawb nqa endothelial cell proliferation.BMP-2, BMP-4, thiab BMP-6 yog synthesized los ntawm megakaryocytes thiab tso tawm los ntawm platelets nyob rau hauv acidic hypoxic ib puag ncig ntawm pob txha tawg.Tseeb, nws tau raug qhia tias PRP txhawb kev sib txawv ntawm cov myoblasts thiab osteoblasts nyob rau hauv lub xub ntiag ntawm BMP-2, BMP-4, BMP-6, thiab BMP-7 tej zaum los ntawm kev ua lub luag haujlwm muaj zog hauv BMP-dependent osteoblastic txawv.
Post lub sij hawm: Oct-13-2022